منابع مشابه
Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.
The structure of altemicidin, a new acaricidal and antitumor agent, was determined to be (1R,2S,3aR,7aS)-4-carbamoyl-2-hydroxy-6-methyl-1-(sulfamo ylacetamido)-2,3,3a,6, 7,7a-hexahydro-6-azaindene-1-carboxylic acid by a combination of spectroscopic and X-ray crystallographic analysis of its derivatives. Altemicidin is a monoterpene alkaloid.
متن کاملInitiating an antitumor attack.
Designing proteins with cavities In de novo protein design, creating custom-tailored binding sites is a particular challenge because these sites often involve nonideal backbone structures. For example, curved b sheets are a common ligand binding motif. Marcos et al. investigated the principles that drive b-sheet curvature by studying the geometry of b sheets in natural proteins and folding simu...
متن کاملNMR analysis of quinocycline antibiotics: structure determination of kosinostatin, an antitumor substance from Micromonospora sp. TP-A0468.
A quinocycline antibiotic, kosinostatin, was isolated from the culture broth of Micromonospora sp. TP-A0468 along with isoquinocycline B. Structure of kosinostatin was determined to be the stereoisomer of isoquinocycline B regarding to the stereochemistry at the C-2' spiro carbon by NMR analysis. Kosinostatin isomerizes to isoquinocycline B through the inversion of the stereocenter at C-2'. Com...
متن کاملA new antitumor substance, BE-18591, produced by a streptomycete. II. Structure determination.
In the course of screening for new antitumor substances, BE-18591 (la) was isolated from cultures of Streptomyces sp. BA18591X). The isolation and physico-chemical properties together with biological activities are reported in the preceding paper. In this paper, the structure elucidation is described. The physico-chemical properties of la were summarized in a previous paper1*. The molecular for...
متن کاملA new indolopyrrolocarbazole antitumor substance, ED-110, a derivative of BE-13793C.
^TV-dimethylformamide (DMF, 37 ml) was added potassium carbonate (510mg, 3.69mmol) and benzyl bromide (170^1, 1.43mmol) at room temperature (r.t.). The mixture was stirred at r.t. for 2hours and extracted with ethyl acetate (200ml) after the addition of water (200 ml). The ethyl acetate layer was concentrated under reduced pressure and the residue was chromatographedon silica gel to obtain 1,1l...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1964
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.37.747